San Francisco is the fifth team in league history to lose three straight Super Bowls, a streak that follows it winning in its first five appearances in the big game.
The fan base is not happy.
The number of years without a title now sits at 29 and the fan base wasted little time lashing out.
Footage surfaced at a Las Vegas casino showing 49ers fans fighting.
On the other side, Kansas City won the Super Bowl for the second consecutive year and the third time in five.